YS121

Names

[ Name ]:
YS121

[Synonym ]:
Octanoic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
YS121
Pirinixic acid-based compound,6a
2-({4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl}sulfanyl)octanoic acid

Biological Activity

[Description]:

YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 μM) and 5-lipoxygenase (5-LOX; IC50=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC50=12 μM in IL-1β-stimulated A549 cells[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> PGE synthase

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[References]

[1]. Hui-Hua Chang, et al. Identification and development of mPGES-1 inhibitors: where we are at?. Future Med Chem. 2011 Nov;3(15):1909-34.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
557.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₆ClN₃O₂S

[ Molecular Weight ]:
407.957

[ Flash Point ]:
290.9±30.1 °C

[ Exact Mass ]:
407.143433

[ PSA ]:
100.41000

[ LogP ]:
7.93

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.601

Synthetic Route

Click to get detail synthetic route

Related Compounds

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