Furowanin A

Names

[ Name ]:
Furowanin A

[Synonym ]:
6-(3,4-Dihydroxyphenyl)-4-hydroxy-2-(2-hydroxy-2-propanyl)-9-(3-methyl-2-buten-1-yl)-2,3-dihydro-5H-furo[3,2-g]chromen-5-one
5H-Furo[3,2-g][1]benzopyran-5-one, 6-(3,4-dihydroxyphenyl)-2,3-dihydro-4-hydroxy-2-(1-hydroxy-1-methylethyl)-9-(3-methyl-2-buten-1-yl)-

Biological Activity

[Description]:

Furowanin A is a flavonoid with anti-neoplastic effects. Furowanin A inhibits STAT3/Mcl-1 axis to suppress proliferation, block cell cycle progression, induce apoptosis and promote autophagy. Furowanin A potently inhibits colorectal cancer (CRC) cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> STAT

[Target]

Mcl-1

STAT3

[References]

[1]. Ma Z, et al. Furowanin A-induced autophagy alleviates apoptosis and promotes cell cycle arrest via inactivation STAT3/Mcl-1 axis in colorectal cancer. Life Sci. 2019 Feb 1;218:47-57.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
697.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₂₆O₇

[ Molecular Weight ]:
438.47

[ Flash Point ]:
240.3±25.0 °C

[ Exact Mass ]:
438.167847

[ PSA ]:
120.36000

[ LogP ]:
5.34

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.661

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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