Dasatinib N-Oxide

Names

[ Name ]:
Dasatinib N-Oxide

[Synonym ]:
N-[2-Chloro-6-methylphenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide N-Oxide
Dasatinib N-Oxide
Dasatinib Impurity 7

Biological Activity

[Description]:

Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].

[Related Catalog]:

Research Areas >> Cancer

[In Vivo]

Dasatinib N-oxide is the pharmacologically active metabolite after oral administration[1].

[References]

[1]. Christopher LJ, et, al. Metabolism and disposition of dasatinib after oral administration to humans. Drug Metab Dispos. 2008 Jul;36(7):1357-64.

[2]. Furlong MT, et, al. A validated LC-MS/MS assay for the simultaneous determination of the anti-leukemic agent dasatinib and two pharmacologically active metabolites in human plasma: application to a clinical pharmacokinetic study. J Pharm Biomed Anal. 2012 Jan 25;58:130-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₆ClN₇O₃S

[ Molecular Weight ]:
504.00500

[ Exact Mass ]:
503.15100

[ PSA ]:
164.43000

[ LogP ]:
3.80690

[ Storage condition ]:
-20°C

Dasatinib N-Oxide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds