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BPU-11

Names

[ CAS No. ]:
909664-41-1

[ Name ]:
BPU-11

Biological Activity

[Description]:

BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Membrane Transporter/Ion Channel >> HCN Channel

[In Vitro]

BPU-11 (100 μM) 消除了 HCN4 cAMP 诱导的 V1/2 位移，k1/2 为 0.42 μM[1]。 BPU (100 和 200 μM) 是 HCN4 亚型特异性的，对 HEK293T 细胞中表达的 HCN2 通道无影响[1]。

[References]

[1]. Lolicato M, et al. Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nat Chem Biol. 2014 Jun;10(6):457-62.  

Chemical & Physical Properties

[ Molecular Formula ]:
C32H31N5O

[ Molecular Weight ]:
501.62144

Related Compounds