JTE-852

JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively; JTE-852 is less potent for Lck (IC50=80 nM), and has IC50 of >300 nM against a kinase panel screenings; inhibits the kinase activity of Syk in an intracellular condition, suppresses the secretion of histamine, LTC4/D4/E4, TXA2, PGD2, and IL-13 from mast cells stimulated by IgE-crosslinking with IC50 of 40-100 nM; attenuates IgG-mediated responses and signs in animal model of autoimmune diseases.

References 1. Kato T, et al. Eur J Pharmacol. 2017 Apr 15;801:1-8. 2. Kato T, et al. Life Sci. 2017 Dec 15;191:166-174. 3. Kato T, et al. J Vet Med Sci. 2018 Jan 26. doi: 10.1292/jvms.17-0659. View Related Products by Target Syk