NSC 694623

Names

[ Name ]:
NSC 694623

Biological Activity

[Description]:

NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with an IC50 value of 15.9 μM for recombinant HAT p300/CBP-associated factor (PCAF). NSC 694623 has antiproliferative activity against certain cancer cells. NSC 694623 can be used for researching anticancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Acetyltransferase

[Target]

PCAF:15.9 μM (IC50)

[In Vitro]

NSC 694623 has antiproliferative activity against SK-N-SH with an IC50 of 8.93 μM, and inhibits 21% of HCT116 at 25 μM[1].

[References]

[1]. Furdas SD, et al. Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₆N₂OS

[ Molecular Weight ]:
284.38

Related Compounds

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