β-LactaMase

Names

[ CAS No. ]:
9073-60-3

[ Name ]:
β-LactaMase

[Synonym ]:
MFCD00131819

Biological Activity

[Description]:

β-Lactamase is the enzyme produced by bacteria. β-Lactamase mediates β-lactam resistance[1].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

在革兰氏阴性菌中，水解四元 β-内酰胺环的酰胺键是 β-Lactamase 主要的耐药机制，多种酶散布在机会致病菌：肠杆菌科 (如大肠杆菌) 和非发酵生物 (如铜绿假单胞菌) 的移动遗传元件上。β-Lactamase 分为四类：活性位点丝氨酸 β-Lactamase (A、C 和 D 类) 和锌依赖性或金属 β-Lactamase (MBLs; B 类)[1]。

[References]

[1]. Tooke CL, et al. β-Lactamases and β-Lactamase Inhibitors in the 21st Century. J Mol Biol. 2019 Aug 23;431(18):3472-3500.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H317-H334

[ Precautionary Statements ]:
P261-P280-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

[ RTECS ]:
OD2265000

Preparation

Articles

A Novel Microbisporicin Producer Identified by Early Dereplication during Lantibiotic Screening.

Biomed Res. Int. 2015 , 419383, (2015)

With the increasing need of effective antibiotics against multi-drug resistant pathogens, lantibiotics are an attractive option of a new class of molecules. They are ribosomally synthetized and posttr...

Identification of peptide inhibitors of penicillinase using a phage display library.

Anal. Biochem. 494 , 4-9, (2015)

There is a constant need to identify novel inhibitors to combat β-lactamase-mediated antibiotic resistance. In this study, we identify three penicillinase-binding peptides, P1 (DHIHRSYRGEFD), P2 (NIYT...

Outbreak of PER-1 and diversity of β-lactamases among ceftazidime-resistant Pseudomonas aeruginosa clinical isolates.

J. Med. Microbiol. 63(Pt 3) , 386-92, (2014)

A growing number of β-lactamases have been reported in Pseudomonas aeruginosa clinical isolates. The aim of this study was to investigate the diversity of β-lactamases in the collection of 51 ceftazid...