Fucoidan

Names

[ Name ]:
Fucoidan

[Synonym ]:
MFCD00131109
(2ξ,6S)-2,6-Anhydro-1-deoxy-6-methyl-5-O-sulfo-D-arabino-hexitol
D-galacto-Heptitol, 2,6-anhydro-1,7-dideoxy-, 3-(hydrogen sulfate), (6ξ)-
[(2S,3S,4S,5S,6R)-4,5-dihydroxy-2,6-dimethyl-tetrahydropyran-3-yl] hydrogen sulfate
(2S,3S,4S,5S,6R)-4,5-dihydroxy-2,6-dimethyltetrahydro-2H-pyran-3-yl hydrogen sulfate

Biological Activity

[Description]:

Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Research Areas >> Metabolic Disease

[In Vitro]

Fucoidan is a biologically active polysaccharide found in great abundance in brown marine algae[1]. Fucoidan extracted from A. nodosum is a more potent inhibitor of α-glucosidase, with an IC50 ranging from 0.013 to 0.047 mg/mL, than the inhibition by Fucoidan extracted from F. vesiculosus (IC50=0.049 mg/mL). Fucoidan extracted from F. vesiculosus does not inhibit α-amylase activity, while Fucoidan from A. nodosum decreases α-amylase activity by 7-100% at 5 mg/mL depending upon the algae harvest period. Fucoidan from A. nodosum inhibits α-amylase with an IC50 of 0.12-4.64 mg/mL[1]. Fucoidan is a fucose-rich sulfated polysaccharide typically found in the cell wall of marine algae but also recently isolated from terrestrial sources. Fucoidan exhibits an attractive therapeutic potential against a wide array of metabolic diseases associated with oxidative stress[2].

[In Vivo]

Fucoidan (single injection of 25 mg/kg/body) does not inhibit tumor cell proliferation, while three-time injections of 10 mg/kg/body weight significantly reduces tumor growth and metastasis[3]. Animal Model: Mice[3] Dosage: 10-400 mg/kg Administration: Intraperitoneal injection; followed by total-body irradiation Result: The mice injected with 100 mg/kg showed the best survival rate at 30 days post-irradiation.

[References]

[1]. Kyung-Tae Kim, et al. Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum.Phytochemistry. 2014 Feb;98:27-33.

[2]. Zeinab El Rashed, et al. Antioxidant and Antisteatotic Activities of Fucoidan Fractions from Marine and Terrestrial Sources. Molecules. 2021 Jul 24;26(15):4467.

[3]. Farzaneh Atashrazm, et al. Fucoidan and cancer: a multifunctional molecule with anti-tumor potential. Mar Drugs. 2015 Apr 14;13(4):2327-46.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₁₄O₇S

[ Molecular Weight ]:
242.24700

[ Exact Mass ]:
242.04600

[ PSA ]:
121.67000

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
C

[ Risk Phrases ]:
34

[ Safety Phrases ]:
26-27-36/37/39-45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Antiproliferative activity of fucan nanogel.

Mar. Drugs 10(9) , 2002-22, (2012)

Sulfated fucans comprise families of polydisperse natural polysaccharides based on sulfated L-fucose. Our aim was to investigate whether fucan nanogel induces cell-specific responses. To that end, a n...

Targeting P-selectin by gallium-68-labeled fucoidan positron emission tomography for noninvasive characterization of vulnerable plaques: correlation with in vivo 17.6T MRI.

Arterioscler. Thromb. Vasc. Biol. 34(8) , 1661-7, (2014)

Nuclear imaging of active plaques still remains challenging. Advanced atherosclerotic plaques have a strong expression of P-selectin by the endothelium overlying active atherosclerotic plaques, but no...

Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects.

Br. J. Nutr. 110(5) , 880-90, (2013)

Laminaria japonica is traditionally eaten in Japan as a beneficial food for thrombosis. The alga contains two specific ingredients, a xanthophyll fucoxanthin (FX) and a polysaccharide, F-fucoidan (FD)...