MI-223

Names

[ Name ]:
MI-223

Biological Activity

[Description]:

MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents; not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress; exhibits a strong synergy against lung cancer in vivo combined with Olaparib.

[References]

References 1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516. View Related Products by Target Bcl-2

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₈ClN₃O₃

[ Molecular Weight ]:
419.865

Related Compounds

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