NSC260594

NSC260594 (NSC 260594) is a specific inhibitor of HIV-1 RNA packaging, which involves preventing the interaction of Gag with SL3 by stabilizing this small RNA stem-loop which then leads to stabilization of the global packaging signal region (psi or ψ); specifically blocks HIV-1 RNA encapsidation, binds to HIV-1 gRNA and exhibits potent antiviral activity; NSC260594 also is a small molecule inhibitor of the Escherichia coli condensin MukBEF, affects MukB directly.

References 1. Ingemarsdotter CK, et al. Retrovirology. 2018 Mar 14;15(1):25. 2. Zhao H, et al. ACS Infect Dis. 2018 Oct 22. doi: 10.1021/acsinfecdis.8b00222. View Related Products by Target HIV