GSK-3 BETA
Names
[ CAS No. ]:
9059-09-0
[ Name ]:
GSK-3 BETA
[Synonym ]:
N,N'-Di(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)-1,6-hexanediamine
N,N'-di(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)hexane-1,6-diamine
1,6-Hexanediamine, N,N-bis(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)-
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
746.6±60.0 °C at 760 mmHg
[ Molecular Formula ]:
C34H42N4
[ Molecular Weight ]:
506.724
[ Flash Point ]:
405.3±32.9 °C
[ Exact Mass ]:
506.340942
[ LogP ]:
10.75
[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C
[ Index of Refraction ]:
1.664
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
Articles
ACS Chem. Neurosci. 6 , 911-9, (2015)
Many current therapies target G protein coupled receptors (GPCR), transporters, or ion channels. In addition to directly targeting these proteins, disrupting the protein-protein interactions that loca...
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation.Nature 406(6791) , 86-90, (2000)
Glycogen synthase kinase-3 (GSK-3)-alpha and -beta are closely related protein-serine kinases, which act as inhibitory components of Wnt signalling during embryonic development and cell proliferation ...
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.Genes Dev. 12(22) , 3499-511, (1998)
The activities of cyclin D-dependent kinases serve to integrate extracellular signaling during G1 phase with the cell-cycle engine that regulates DNA replication and mitosis. Induction of D-type cycli...