Dextran sulfate sodium

Names

[ Name ]:
Dextran sulfate sodium

[Synonym ]:
MFCD00081551

Biological Activity

[Description]:

Dextran sulfate sodium salt (MW 16000-24000) is a is a polymer of anhydroglucose with the molecular weight range of 16000-24000. Dextran sulfate sodium salt inhibits the replication of the human immunodeficiency virus by preventing the adsorption of the virus into host cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Signaling Pathways >> Anti-infection >> HIV

Signaling Pathways >> Others >> Others

[References]

[1]. Baba M, et al. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6132-6.

Chemical & Physical Properties

[ Molecular Formula ]:
(C₆H₇Na₃O₁₄S₃)n

[ Appearance of Characters ]:
powder | White to off-white

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 100 mg/mL | Soluble in water.

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi,Xn

[ Risk Phrases ]:
20/21/22-36/37/38

[ Safety Phrases ]:
26-36-37/39-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
HH9290000

Articles

Prevention of venous thromboembolism.

Chest 108(4 Suppl) , 312S-334S, (1995)

A comparison of albumin and saline for fluid resuscitation in the intensive care unit.

N. Engl. J. Med. 350(22) , 2247-56, (2004)

It remains uncertain whether the choice of resuscitation fluid for patients in intensive care units (ICUs) affects survival. We conducted a multicenter, randomized, double-blind trial to compare the e...

TLR4 monoclonal antibody blockade suppresses dextran-sulfate-sodium-induced colitis in mice.

J. Gastroenterol. Hepatol. 25(1) , 209-14, (2010)

Ulcerative colitis (UC) refers to a kind of inflammatory bowel disease, of which the accurate pathogenesis is not yet well understood. Recently, the toll-like receptor 4 (TLR4) and the TLR4 signaling ...

Related Compounds

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