Calcium alginate

Names

[ Name ]:
Calcium alginate

[Synonym ]:
calcium,(2S,3S,4S,5S,6R)-6-[(2R,3S,4R,5S,6R)-2-carboxy-6-[(2R,3S,4R,5S,6R)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate
MFCD00143567

Biological Activity

[Description]:

Calcium alginate is a biopolymer that can be used for developing oral drug-delivery systems[1]. Calcium alginate is a pH sensitive hydrogel stable in acidic media and soluble in basic media[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Calcium alginate is a pH sensitive hydrogel stable in acidic media and soluble in basic media. This enables the hydrogel to absorb and release aqueous solutions at certain ranges of pH values. By absorbing an aqueous solution containing a drug, an active drug release can be triggered at a specified range of pH value[2]. Calcium alginate is a biodegradable gel-transforming agent widely used for nasal packing. It can reduce pain and improve comfort[3].

[References]

[1]. Demitri C, et al. Encapsulation of Lactobacillus kefiri in alginate microbeads using a double novel aerosol technique. Mater Sci Eng C Mater Biol Appl. 2017;77:548-555.

[2]. Chengzhi Hu, et al. Electrosynthesis of magnetoresponsive microrobot for targeted drug delivery using calcium alginate. Annu Int Conf IEEE Eng Med Biol Soc. 2016;2016:2111-2114.

[3]. Park DY, et al. Comparison of calcium alginate and carboxymethyl cellulose for nasal packing after endoscopic sinus surgery: a prospective, randomised, controlled single-blinded trial. Clin Otolaryngol. 2016;41(3):234-240.

Chemical & Physical Properties

[ Density]:
2.1173 g/cm3

[ Molecular Formula ]:
C₃₆H₄₂Ca₃O₃₆

[ Molecular Weight ]:
1170.93000

[ Exact Mass ]:
1170.03000

[ PSA ]:
511.32000

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AZ5810000

CHEMICAL NAME :: Alginic acid, calcium salt

CAS REGISTRY NUMBER :: 9005-35-0

LAST UPDATED :: 199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1407 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,381,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,381,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83092 No. of Facilities: 47 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83092 No. of Facilities: 643 (estimated) No. of Industries: 16 No. of Occupations: 7 No. of Employees: 3968 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AZ5820000

Articles

Safety and efficacy of ethylenediaminetetraacetic acid for removing microcapsules.

J. Surg. Res. 183(1) , 442-9, (2013)

Microencapsulated islets are used to prevent immune rejection associated with pancreatic islet transplantation, but cellular overgrowth affects transplantation success, necessitating removal of microc...

Optimization of sustained release matrix tablet of metoprolol succinate using central composite design.

Pak. J. Pharm. Sci. 26(5) , 929-37, (2013)

The present study was performed to optimize the formulation of metoprolol succinate (MS) sustained release tablets using hydroxypropyl methylcellulose (HPMC) and sodium alginate (SA) as the matrix com...

Baicalein and hydroxypropyl-γ-cyclodextrin complex in poloxamer thermal sensitive hydrogel for vaginal administration.

Int. J. Pharm. 454(1) , 125-34, (2013)

The present study aimed to prepare a chemically and physically stable formulation of baicalein (Ba) in an in situ thermally sensitive hydrogel for vaginal administration. An inclusion complex of Ba an...