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tsh

Names

[ CAS No. ]:
9002-71-5

[ Name ]:
tsh

[Synonym ]:
L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-, acetate (1:1)
MFCD00166060
5-Oxo-L-prolyl-L-histidyl-L-prolinamide acetate (1:1)
EINECS 232-664-4

Biological Activity

[Description]:

Thyrotropin (TSH) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid[1][2].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[References]

[1]. Wolf G. The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid. Nutr Rev. 2002 Nov;60(11):374-7.

[2]. Vassart G, et al. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev. 1992 Aug;13(3):596-611.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H26N6O6

[ Molecular Weight ]:
422.436

[ Exact Mass ]:
422.191376

[ Appearance of Characters ]:
lyophilized powder

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
B

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
XP3581600

Articles

Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species.

Endocrinology 156(4) , 1540-51, (2015)

Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cel...

Effects of magnesium on cytomorphology and enzyme activities in thyroid of rats.

Indian J. Exp. Biol. 52(8) , 787-92, (2014)

Till date knowledge regarding the effects of high dietary magnesium on thyroid gland is incomprehensive though certain epidemiological studies reported development of thyroid gland dysfunctions in peo...

Extreme phenotypic variability of thyroid dysgenesis in six new cases of congenital hypothyroidism due to PAX8 gene loss-of-function mutations.

Eur. J. Endocrinol. 171(4) , 499-507, (2014)

Within the last two decades, heterozygous loss-of-function PAX8 mutations have been reported in patients with a wide degree of thyroid gland dysfunction and growth despite the presence of identical mu...


More Articles

Related Compounds