Parathyroid

Parathyroid hormone (PTH) is a circulating hormone comprised of 84 amino acids. Parathyroid hormone is produced in the parathyroid glands and acts primarily on bone and kidney to maintain extracellular calcium levels within normal limits. Parathyroid hormone can be used for osteoporosis research[1].

Research Areas >> Endocrinology

Human Endogenous Metabolite

Parathyroid hormone (PTH) has biphasic effects on bone: continuous treatment is catabolic whereas intermittent treatment is anabolic[2]. Parathyroid hormone secretion can be improved by physical exercise[2].

Parathyroid hormone (hPTH1–34) (40 μg/kg, s.c.; daily for 2 weeks) exerts a catabolic effect on mouse bone with a significant decrease in trabecular connectivity density[3]. Animal Model: 10-week-old female C57BL/J6 mice[3] Dosage: 40 μg/kg Administration: Subcutaneous injection, daily for 2 weeks Result: Significantly suppressed endogenous intact mPTH1–84 from 2.40 ± 0.55 pM (control) to 0.73 ± 0.25 pM, and significantly increased total serum calcium levels from 1.95 to 2.64 mM.

[1]. Gensure RC, et al. Parathyroid hormone and parathyroid hormone-related peptide, and their receptors. Biochem Biophys Res Commun. 2005 Mar 18;328(3):666-78.

[2]. Bouassida A, et al. Parathyroid hormone and physical exercise: a brief review. J Sports Sci Med. 2006 Sep 1;5(3):367-74.

[3]. Iida-Klein A, et al. Short-term continuous infusion of human parathyroid hormone 1-34 fragment is catabolic with decreased trabecular connectivity density accompanied by hypercalcemia in C57BL/J6 mice. J Endocrinol. 2005 Sep;186(3):549-57.