TYROSINASE

Names

[ Name ]:
TYROSINASE

[Synonym ]:
EINECS 232-653-4

Biological Activity

[Description]:

Tyrosinase (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin and is encoded by TYR gene. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

Research Areas >> Metabolic Disease

[References]

[1]. Sánchez-Ferrer A, et al. Tyrosinase: a comprehensive review of its mechanism. Biochim Biophys Acta. 1995 Feb 22;1247(1):1-11.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1578.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₂H₆₆N₁₀O₁₆S₂

[ Molecular Weight ]:
1031.161

[ Flash Point ]:
908.2±34.3 °C

[ Exact Mass ]:
1030.409912

[ LogP ]:
-1.38

[ Appearance of Characters ]:
lyophilized powder

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.590

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
42

[ Safety Phrases ]:
22-24/25-45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

Articles

Separation of the antioxidant compound quercitrin from Lindera obtusiloba Blume and its antimelanogenic effect on B16F10 melanoma cells.

Biosci. Biotechnol. Biochem. 77(1) , 58-64, (2013)

Considering the growing evidence of the presence of antioxidant compounds in plant extracts, the objectives of this study were to identify antioxidant compounds in Lindera obtusiloba Blume (Lauraceae)...

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res. 14 , 2121-7, (2004)

The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for...

Standardised herbal extract of chlorogenic acid from leaves of Etlingera elatior (Zingiberaceae).

Pharmacognosy Res. 3 , 178-184, (2011)

Chlorogenic acid (CGA) or 5-caffeoylquinic acid, was found to be the dominant phenolic compound in leaves of Etlingera elatior (Zingiberaceae). The CGA content of E. elatior leaves was significantly h...