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Bromelain

Names

[ CAS No. ]:
9001-00-7

[ Name ]:
Bromelain

[Synonym ]:
2-[(3-Aminopropanoyl)amino]-3-(1H-imidazol-4-yl)propanoic acid
Histidine, β-alanyl-
b-Alanylhistidine
β-Alanylhistidine
carnosine
N-(3-Aminopropanoyl)histidine
EINECS 253-387-5

Biological Activity

[Description]:

Bromelain is an anti-inflammatory drug derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway[1]. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vivo]

Bromelain (40 mg/kg; intraperitoneal injection; daily; for 7 days; male Sprague-Dawley rats) pretreatment reduces the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD). 6-OHDA injection resulted in marked motor impairment which is prevented by pretreatment with Bromelain prior to the lesion[1]. Animal Model: Male Sprague-Dawley rats injected with 6-OHDA[1] Dosage: 40 mg/kg Administration: Intraperitoneal injection; daily; for 7 days Result: Reduced the motor dysfunction in the parkinsonian rat model of parkinson's disease (PD).

[References]

[1]. Adu TS, et al. Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism. Metab Brain Dis. 2019 Jul 22.

[2]. Pavan R, et al. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
656.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H14N4O3

[ Molecular Weight ]:
226.232

[ Flash Point ]:
350.7±31.5 °C

[ Exact Mass ]:
226.106583

[ LogP ]:
-2.17

[ Appearance of Characters ]:
powder | yellow-brown

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Storage condition ]:
−20°C

[ Water Solubility ]:
soluble

Safety Information

[ Hazard Codes ]:
B,Xn

[ Risk Phrases ]:
36/37/38-42

[ Safety Phrases ]:
22-24-26-36/37

[ WGK Germany ]:
3

[ HS Code ]:
35079090

Related Compounds