Diethylcarbamazine

Names

[ CAS No. ]:
90-89-1

[ Name ]:
Diethylcarbamazine

[Synonym ]:
patonin
4-methyl-piperazine-1-carboxylic acid diethylamide
Caracide
84L
Caricide
Notezine
rp3799
Cypip
diethycarbamazine
Banocide
4-Methyl-piperazin-1-carbonsaeure-diaethylamid
Diethylcarbamazine
Ethodryl

Biological Activity

[Description]:

Diethylcarbamazine is a microfilaricidal drug used originally in onchocerciasis and lymphatic filiariasis study[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. M García-Hernández, et al. Immunomodulatory effect of diethylcarbamazine in mice infected with Nocardia brasiliensis. Int Immunopharmacol. 2014 Nov;23(1):113-20.

Chemical & Physical Properties

[ Density]:
1.013g/cm3

[ Boiling Point ]:
139ºC

[ Melting Point ]:
137 - 140ºC

[ Molecular Formula ]:
C₁₀H₂₁N₃O

[ Molecular Weight ]:
199.29300

[ Flash Point ]:
98ºC

[ Exact Mass ]:
199.16800

[ PSA ]:
26.79000

[ LogP ]:
0.57140

[ Index of Refraction ]:
1.492

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL1200000

CHEMICAL NAME :: 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-

CAS REGISTRY NUMBER :: 90-89-1

BEILSTEIN REFERENCE NO. :: 0143029

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H21-N3-O

MOLECULAR WEIGHT :: 199.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 7300 mg/kg/1Y-I

TOXIC EFFECTS :: Skin and Appendages - dermatitis, allergic (after systemic exposure)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 630 mg/kg

SEX/DURATION :: female 7-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 44,7,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2728 No. of Facilities: 316 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 3161 (estimated) No. of Female Employees: 1581 (estimated)