DSM 74

Names

[ Name ]:
DSM 74

Biological Activity

[Description]:

A potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity; shows good plasma exposure in mice and is equally potent against PfDHODH and PbDHODH; suppresses growth of P. berghei in mice after oral administration.

[References]

References 1. Lukens AK, e tal. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804. 2. Gujjar R, et al. J Med Chem. 2009 Apr 9;52(7):1864-72. 3. Lee JJ, et al. urr Microbiol. 2014 Sep;69(3):286-91. View Related Products by Target Bacterial

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₀F₃N₅

[ Molecular Weight ]:
293.253

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.