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Luseogliflozin

Names

[ CAS No. ]:
898537-18-3

[ Name ]:
Luseogliflozin

[Synonym ]:
TS-071
Luseogliflozin
Lusefi
(1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol
D-Glucitol, 1,5-anhydro-1-C-[5-[(4-ethoxyphenyl)methyl]-2-methoxy-4-methylphenyl]-1-thio-, (1S)-
UNII-C596HWF74Z
TS-71
TS 071

Biological Activity

[Description]:

Luseogliflozin (TS 071) is a potent, selective, orally active sodium-dependent glucose cotransporter (SGLT) 2 inhibitor, with an IC50 of 2.26 nM, about 1765-fold selectivity over SGLT1 (IC50, 3990 nM). Luseogliflozin has the protential for treating type 2 diabetes.

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> SGLT

[Target]

SGLT2:2.26 nM (IC50)

SGLT1:3990 nM (IC50)


[In Vitro]

Luseogliflozin (TS-071, 3p) is a potent sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor, with an IC50 of 2.26 nM, about 1765-fold selectivity over SGLT1 (IC50, 3990 nM); Luseogliflozin has the protential for treating type 2 diabetes[1].

[In Vivo]

Luseogliflozin (1 mg/kg, p.o.) exhibits a blood glucose lowering effect, excellent urinary glucose excretion properties, and promising PK profiles in rats and dogs[1].

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
624.5±55.0 °C at 760 mmHg

[ Melting Point ]:
155.0-157.0℃

[ Molecular Formula ]:
C23H30O6S

[ Molecular Weight ]:
434.546

[ Flash Point ]:
331.5±31.5 °C

[ Exact Mass ]:
434.176300

[ PSA ]:
124.68000

[ LogP ]:
4.43

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.616

Related Compounds