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Trifarotene

Names

[ CAS No. ]:
895542-09-3

[ Name ]:
Trifarotene

[Synonym ]:
4'-(2-Hydroxyethoxy)-3''-(2-methyl-2-propanyl)-4''-(1-pyrrolidinyl)-1,1':3',1''-terphenyl-4-carboxylic acid
[1,1':3',1''-Terphenyl]-4-carboxylic acid, 3''-(1,1-dimethylethyl)-4'-(2-hydroxyethoxy)-4''-(1-pyrrolidinyl)-
Trifarotene
CD5789
UNII-0J8RN2W0HK

Biological Activity

[Description]:

Trifarotene is a retinoic acid receptor (RAR) agonist with Kdapp of 2, 15 and 500 nM for RARγ, RARβ and RARα, respectively.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Research Areas >> Inflammation/Immunology

[Target]

Kdapp: 2 nM (RARγ), 15 nM (RARβ), 500 nM (RARα)[1]


[References]

[1]. Thibaud Biadatti, et al. Novel ligands that modulate rar receptors, and use thereof in human medicine and in cosmetics. WO 2006066978 A1.


[Related Small Molecules]

Retinoic acid | AM580 | Tamibarotene | Palovarotene | Fenretinide | TTNPB | Magnolol | AGN 194310 | AGN 193109 | CD437 | Adapalene | AR-7 | Tazarotene | UVI 3003 | Tarenflurbil

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
641.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H33NO4

[ Molecular Weight ]:
459.577

[ Flash Point ]:
342.0±31.5 °C

[ Exact Mass ]:
459.240967

[ PSA ]:
70.00000

[ LogP ]:
6.27

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.599

[ Storage condition ]:
2-8℃

Related Compounds