LDH-IN-2

Names

[ Name ]:
LDH-IN-2

Biological Activity

[Description]:

LDH-IN-2, a salicylic acid derivative, is an inhibitor of glycolate oxidase (GO). LDH-IN-2 decreases oxalate output in hyperoxaluric hepatocytes. LDH-IN-2 can be used for research of primary hyperoxaluria type 1 (PH1)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

LDH-IN-2L (compound 34) (10 μM; 24 h) 在 Agxt1-/- 小鼠原代肝细胞中抑制草酸产生的抑制率为 89%[1]。

[References]

[1]. Moya-Garzón MD, et al. Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1. J Med Chem. 2018 Aug 23;61(16):7144-7167.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₈O₄

[ Molecular Weight ]:
204.18

Related Compounds

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