2-Oxopropanoate-13c2 sodium

Names

[ Name ]:
2-Oxopropanoate-13c2 sodium

[Synonym ]:
PYRUVIC-2 3-13C2 ACID SODIUM SALT
Pyruvic acid-2,3-13C2 sodium salt
SODIUM PYRUVATE-2,3-13C2
Sodium Pyruvate-13C3
SODIUM PYRUVATE-2 3-13C2
MFCD00084083

Biological Activity

[Description]:

2-Oxopropanoate-13C5 (sodium) is the 13C labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. S Nemoto, et al. Role for mitochondrial oxidants as regulators of cellular metabolism. Mol Cell Biol. 2000 Oct;20(19):7311-8.

[3]. W Zhao, et al. Fructose induced deactivation of antioxidant enzymes: preventive effect of pyruvate. Free Radic Res. 2000 Jul33(1):23-30.