15,16-Dihydrotanshindiol C

Names

[ Name ]:
15,16-Dihydrotanshindiol C

[Synonym ]:
Phenanthro[1,2-b]furan-10,11-dione, 1,2,6,7,8,9-hexahydro-6,7-dihydroxy-1,6-dimethyl-, (6R,7R)-
(6R,7R)-6,7-Dihydroxy-1,6-dimethyl-1,2,6,7,8,9-hexahydrophenanthro[1,2-b]furan-10,11-dione
15,16-Dihydrotanshindiol C

Biological Activity

[Description]:

15,16-Dihydrotanshindiol C, a diterpenoid, is a potent thrombin inhibitor[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin

[References]

[1]. Elwira Sieniawska, et al. Tanshinones from Salvia miltiorrhiza inhibit Mycobacterium tuberculosis via disruption of the cell envelope surface and oxidative stress. Food Chem Toxicol. 2021 Oct;156:112405.

[2]. Jun Lu, et al. Screening of direct thrombin inhibitors from Radix Salviae Miltiorrhizae by a peak fractionation approach.J Pharm Biomed Anal. 2015 May 10;109:85-90.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
534.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₈O₅

[ Molecular Weight ]:
314.332

[ Flash Point ]:
198.3±23.6 °C

[ Exact Mass ]:
314.115417

[ LogP ]:
1.71

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.659

[ Water Solubility ]:
Very slightly soluble (0.88 g/L) (25 ºC)

Related Compounds

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