Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 trifluoroacetate salt

Names

[ Name ]:
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 trifluoroacetate salt

[Synonym ]:
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2
390 MMP FRET SUBSTRATE (V)

Biological Activity

[Description]:

Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.85*105 M-1s-1, and poor substrate of other MMPs with the exception of MMP13 (kcat/Km = 0.53*105 M-1s-1) and MMP9 (0.33*105 M-1s-1)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

others

[References]

[1]. Sarah Bregant, et al. Detection of matrix metalloproteinase active forms in complex proteomes: evaluation of affinity versus photoaffinity capture. J Proteome Res. 2009 May;8(5):2484-94.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₃H₇₀N₁₂O₂₀

[ Molecular Weight ]:
1195.19000

[ Exact Mass ]:
1194.48000

[ PSA ]:
484.81000

[ LogP ]:
4.10950

Related Compounds

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