DU011

Names

[ Name ]:
DU011

Biological Activity

[Description]:

DU011 is a noncanonical anti-infective agent and small-molecule inhibitor of capsule biogenesis, targets MprA (Kd=30 nM), a MarR family transcriptional repressor of multidrug efflux pumps, inhibits capsule expression in E. coli.DU011 does not alter Escherichia coli antibiotic resistance and has significantly enhanced inhibition of capsule expression, compared with other proposed MprA ligands, such as salicylate and 2,4-dinitrophenol (DNP).

[References]

1. Arshad M, et al. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01208-20.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₅F₂NO₄S

[ Molecular Weight ]:
403.400

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.