2-Propanone, 1-(2-methoxyethoxy)- (9CI)

Names

[ Name ]:
2-Propanone, 1-(2-methoxyethoxy)- (9CI)

[Synonym ]:
2-Propanone,1-(2-methoxyethoxy)
1-(2-methoxyethoxy)acetone
(2-Methoxy-aethoxy)-aceton
(2-methoxy-ethoxy)-acetone

Biological Activity

[Description]:

PROTAC Linker 28 is a PROTAC linker, which refers to the alkyl chain composition. PROTAC Linker 28 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₂O₃

[ Molecular Weight ]:
132.15800

[ Exact Mass ]:
132.07900

[ PSA ]:
35.53000

[ LogP ]:
0.23840

Safety Information

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%