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U 60257B

Names

[ CAS No. ]:
88851-62-1

[ Name ]:
U 60257B

[Synonym ]:
Cyclopenta[b]pyrrole-2-pentanoic acid, 1,4,5,6-tetrahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-1-octen-1-yl]-1-phenyl-, potassium salt, (4R,5R)- (1:1)
[4R-[4a(1E,3S*),5b]]-1,4,5,6-Tetrahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-1-phenylcyclopenta[b]pyrrole-2-pentanoic Acid Monopotassium Salt
u60,257b potassium salt
Potassium (4R,5R)-1,4,5,6-Tetrahydro-5-hydroxy-4-[(E)-(3S)-3-hydroxy-1-octenyl]-1-phenylcyclopenta[b]pyrrole-2-valerate
Potassium 5-{(4R,5R)-5-hydroxy-4-[(1E,3S)-3-hydroxy-1-octen-1-yl]-1-phenyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrol-2-yl}pentanoate
U 60257B

Biological Activity

[Description]:

Piriprost (U-60,257B) potassium is an inhibitor of leukotriene synthesis. Piriprost potassium inhibits the release of both leukotriene and histamine with an IC50 of 0.11 μM from isolated porcine lung cells. Piriprost potassium increases alkaline phosphatase (ALP) activity in cultured endometrial stromal cells[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor
Research Areas >> Inflammation/Immunology

[Target]

IC50: 0.11 μM (leukotriene)[2]


[References]

[1]. Cejic SS, Kennedy TG. Examination of the effects of piriprost (U-60,257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. Prostaglandins. 1991 Aug;42(2):179-89.

[2]. McCormack DG, Paterson NA. The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. Am Rev Respir Dis. 1989 Jan;139(1):100-5.

Chemical & Physical Properties

[ Boiling Point ]:
618.6ºC at 760 mmHg

[ Molecular Formula ]:
C26H34KNO4

[ Molecular Weight ]:
463.65

[ Flash Point ]:
327.9ºC

[ Exact Mass ]:
463.212494

[ PSA ]:
85.52000

[ LogP ]:
3.43800

MSDS

Safety Information

[ Safety Phrases ]:
22-24/25


Related Compounds

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