PEG9-Tos

Names

[ Name ]:
PEG9-Tos

[Synonym ]:
23-Hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl 4-methylbenzenesulfonate
PEG8-Ts
3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol, mono(4-methylbenzenesulfonate)
PEG8-OTs

Biological Activity

[Description]:

PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
615.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₄₀O₁₁S

[ Molecular Weight ]:
524.622

[ Flash Point ]:
325.8±31.5 °C

[ Exact Mass ]:
524.229126

[ LogP ]:
-1.56

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.497

PEG9-Tos

Names

Biological Activity

Chemical & Physical Properties

Related Compounds