Box5

Box5 is a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist; abolishes exogenous Wnt5a stimulation of A2058 cells increased adhesion, migration and invasion, all crucial components of tumor metastasis, also inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling.

References 1. Jenei V, et al. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19473-8. 2. Linnskog R, et al. Oncotarget. 2016 Jun 21;7(25):37790-37802. 3. Yuan S, et al. J Neuroimmune Pharmacol. 2012 Dec;7(4):904-13. 4. Ackers I, et al. Cardiovasc Pathol. 2018 May-Jun;34:1-8. View Related Products by Target Wnt