S-30-Hydroxygambogic acid

Names

[ Name ]:
S-30-Hydroxygambogic acid

[Synonym ]:
(2Z)-2-(Hydroxymethyl)-4-[(1S,2S,8S,17S,19R)-12-hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11 ]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-butenoic acid
2-Butenoic acid, 2-(hydroxymethyl)-4-[(1R,3aS,5S,11S,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-

Biological Activity

[Description]:

S-30-Hydroxygambogic acid is polyprenylated xanthone epimer that can be isolated from gamboges of Garcinia hanburyi. S-30-Hydroxygambogic acid shows cytotoxicities to Human Leukemia K562 cell lines of IC50 values of 4.49 and 3.61 μM for K562/R and K562/S, respectively. S-30-Hydroxygambogic acid can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Han QB, et al. A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges. Chem Biodivers. 2006 Jan;3(1):101-5.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
845.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₈H₄₄O₉

[ Molecular Weight ]:
644.751

[ Flash Point ]:
263.3±27.8 °C

[ Exact Mass ]:
644.298523

[ LogP ]:
9.48

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.639

Related Compounds

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