Cefepime

Names

[ Name ]:
Cefepime

[Synonym ]:
7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(1-methylpyrrolidino)methyl-3-cephem-4-carboxylate
(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-(Z)-(methoxyimino)acetamido]-3-[(1-methyl-1-pyrrolidinium)methyl]-3-cephem-4-carboxylate
MFCD00864890
Pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, inner salt
[6R-[6a,7b(Z)]]-1-[[7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium inner salt
Cefepime
Cefpim
CEFEPIME ARGININE
(6R,7R)-7-{[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methyl-1-pyrrolidiniumyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Tsefepim
(6R,7R)-7-{[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CFPM

Biological Activity

[Description]:

Cefepime is a Cephalosporin with activity against both Gram-positive and Gram-negative aerobic bacteria. Cefepime exerts its antibacterial effects by binding to penicillin-binding proteins[1]. Cefepime has certain neurotoxicity[2].

[Related Catalog]:

Research Areas >> Infection

[Target]

Gram-positive and Gram-negative aerobic bacteria[1]

[References]

[1]. Barradell LB, Bryson HM. Cefepime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1994;47(3):471-505.

[2]. B A Cunha, et al. Cefepime. Med Clin North Am. 1995 Jul;79(4):721-32.

[3]. L Boschung-Pasquier, et al. Cefepime neurotoxicity: thresholds and risk factors. A retrospective cohort study. Clin Microbiol Infect. 2020 Mar;26(3):333-339.

Chemical & Physical Properties

[ Melting Point ]:
150ºC

[ Molecular Formula ]:
C₁₉H₂₄N₆O₅S₂

[ Molecular Weight ]:
480.561

[ Exact Mass ]:
480.124969

[ PSA ]:
203.58000

[ LogP ]:
-1.62

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
7-16-53-45-36/37

[ RIDADR ]:
UN 2924 3/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
CX9850000

[ HS Code ]:
32041300

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 32041300

Related Compounds

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