αA-Conotoxin OIVA

Names

[ CAS No. ]:
878027-87-3

[ Name ]:
αA-Conotoxin OIVA

Biological Activity

[Description]:

αA-Conotoxin OIVA (αA-OIVA) is a selective nAChR antagonist with an IC50 of 56 nM against mammalian fetal muscle nAChR. αA-Conotoxin OIVA is a peptide that can be derived from conotoxin. αA-Conotoxin OIVA paralyzes muscles[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease

[References]

[1]. Teichert RW, et al. A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor. J Neurosci. 2005 Jan 19;25(3):732-6.  

[2]. Teichert RW, et al. AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors. Toxicon. 2004 Aug;44(2):207-14.  

Chemical & Physical Properties

[ Molecular Formula ]:
C70H110N24O23S6

[ Molecular Weight ]:
1848.16

Related Compounds

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