THP-SS-alcohol

Names

[ Name ]:
THP-SS-alcohol

[Synonym ]:
2-{[2-(Tetrahydro-2H-pyran-2-yloxy)ethyl]disulfanyl}ethanol
Ethanol, 2-[[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]dithio]-
MFCD28505568

Biological Activity

[Description]:

THP-SS-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
369.8±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₈O₃S₂

[ Molecular Weight ]:
238.367

[ Flash Point ]:
177.4±27.9 °C

[ Exact Mass ]:
238.069733

[ LogP ]:
1.57

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.547

Related Compounds

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