Filibuvir

Names

[ Name ]:
Filibuvir

[Synonym ]:
Filibuvir
3frz
UNII-198J479Y2L

Biological Activity

[Description]:

Filibuvir is a potent, selective non-nucleoside inhibitor (NNI) of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase, and it binds noncovalently in the “Thumb 2” pocket of NS5B. In vitro, filibuvir is equipotent against genotype 1a and 1b replicons, with an EC50 of 59 nM[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> HCV Protease

[References]

[1]. Wagner F, et al. Antiviral activity of the hepatitis C virus polymerase inhibitor filibuvir in genotype 1-infected patients. Hepatology. 2011 Jul;54(1):50-9.

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Molecular Formula ]:
C₂₉H₃₇N₅O₃

[ Molecular Weight ]:
503.63600

[ Exact Mass ]:
503.29000

[ PSA ]:
102.50000

[ LogP ]:
5.12420

[ Appearance of Characters ]:
white to beige

[ Storage condition ]:
room temp

[ Water Solubility ]:
DMSO: soluble10mg/mL, clear

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport