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Trandolaprilat

Names

[ CAS No. ]:
87679-71-8

[ Name ]:
Trandolaprilat

[Synonym ]:
Trandolaprilat
Trandolaprilatum
Trandolaprilate [INN-French]
Trandolaprilatum [INN-Latin]
Trandolaprilate
UNII-RR6866VL0O

Biological Activity

[Description]:

Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

[Target]

Human Endogenous Metabolite


[References]

[1]. Millet D, et al. Effects of angiotensins on cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells. Eur J Biochem. 1992 Jun 1;206(2):367-72.

[2]. Al-Hawash LA, et al. Stability-indicating HPLC determination of trandolapril in bulk drug and pharmaceutical dosage forms. Int J Anal Chem. 2015;2015:820517.

Chemical & Physical Properties

[ Density]:
1.247 g/cm3

[ Boiling Point ]:
640.5ºC at 760 mmHg

[ Melting Point ]:
132-134ºC

[ Molecular Formula ]:
C22H30N2O5

[ Molecular Weight ]:
402.48400

[ Flash Point ]:
341.2ºC

[ Exact Mass ]:
402.21500

[ PSA ]:
106.94000

[ LogP ]:
2.62360

[ Storage condition ]:
-20°C Freezer

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
29339900

Related Compounds