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Safracin B

Names

[ CAS No. ]:
87578-99-2

[ Name ]:
Safracin B

Biological Activity

[Description]:

Safracin B, a tetrahydroisoquinoline (THIQ) alkaloid, is a naturally occurring antibiotic from Pseudomonas fluorescens. Safracin B exhibits broad spectrum antimicrobial and strong antitumor activities[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection

[In Vivo]

Safracin B (0.005-5 mg/kg/day; for 9 days) prolongs the life span of tumor-bearing mice and shows antitumor activity against L1210 and P388 leukemias and B16 melanoma in Female BALB/c x DBA/2 F1 (CD2F1) mice weighing 19-24 g[2]. The LD50 is 7.3 mg/kg with safracin B in normal CD2F1 mice by ip administration[2].

[References]

[1]. Gong-Li Tang, et al.Biosynthesis of Tetrahydroisoquinoline Antibiotics. Curr Top Med Chem. 2016;16(15):1717-26.

[2]. T Okumoto, et al. Activity of Safracins A and B, Heterocyclic Quinone Antibiotics, on Experimental Tumors in Mice. J Antibiot (Tokyo). 1985 Jun;38(6):767-71.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H36N4O7

[ Molecular Weight ]:
540.60800

[ Exact Mass ]:
540.25800

[ PSA ]:
154.66000

[ LogP ]:
1.18090

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TX1404550
CHEMICAL NAME :
Propanamide, 2-amino-N-((6,7,9,10,13,14,14a,15-octahydro-1,7-dihyd roxy-2,11-dimethoxy- 3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino( 3,2-b)(3)benzazocin-9 -yl)methyl)-
CAS REGISTRY NUMBER :
87578-99-2
LAST UPDATED :
199401
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C28-H36-N4-O7
MOLECULAR WEIGHT :
540.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3540 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #83-113192

Related Compounds

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