PPY A

Names

[ Name ]:
PPY A

Biological Activity

[Description]:

PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba⁄F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl

[References]

[1]. Tianjun Zhou, et al. Crystal structure of the T315I mutant of AbI kinase. Chem Biol Drug Des. 2007 Sep;70(3):171-81.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₀N₄O₂

[ Molecular Weight ]:
372.42000

[ Exact Mass ]:
372.15900

[ PSA ]:
71.11000

[ LogP ]:
4.00230

Related Compounds

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