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3'-Hydroxy Repaglinide

Names

[ CAS No. ]:
874908-14-2

[ Name ]:
3'-Hydroxy Repaglinide

Biological Activity

[Description]:

3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probedrugs and their corresponding metabolites in human serum and urine. Anal Bioanal Chem. 2017 Jan;409(1):251-268.

[2]. Honkalammi J, et al. Mechanism-based inactivation of CYP2C8 by gemfibrozil occurs rapidly in humans. Clin Pharmacol Ther. 2011 Apr;89(4):579-86.

Chemical & Physical Properties

[ Density]:
1.186g/cm3

[ Boiling Point ]:
709.6ºC at 760 mmHg

[ Melting Point ]:
79-82ºC

[ Molecular Formula ]:
C27H36N2O5

[ Molecular Weight ]:
468.58500

[ Flash Point ]:
383ºC

[ Exact Mass ]:
468.26200

[ PSA ]:
102.59000

[ LogP ]:
5.09600

[ Index of Refraction ]:
1.581

[ Storage condition ]:
-20°C

Related Compounds