JNJ-26489112

Names

[ Name ]:
JNJ-26489112

[Synonym ]:
Sulfamide, N-[[(2S)-6-chloro-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]-
N-{[(2S)-6-Chloro-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}sulfuric diamide
JNJ-26489112
G1TI012DLT

Biological Activity

[Description]:

JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures; exhibits very weak inhibition of human CA-II (IC50=35 μM); inhibits Na+, kainate, and KCNQ2 channels to varying degrees, while moderately potentiating GABA current and inhibiting N-methyl-D-aspartic acid current, its action at several targets appears to be responsible for the observed neurostabilizing effects; shows limited seizure spread and elevated seizure threshold in preclinical animal models. Epilepsy Discontinued

[References]

References 1. McComsey DF, et al. J Med Chem. 2013 Nov 27;56(22):9019-30. View Related Products by Target Other Targets Epilepsy

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
457.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₁ClN₂O₄S

[ Molecular Weight ]:
278.713

[ Flash Point ]:
230.7±31.5 °C

[ Exact Mass ]:
278.012817

[ LogP ]:
1.03

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.597

Related Compounds

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