Isolindleyin

Names

[ Name ]:
Isolindleyin

[Synonym ]:
4-(4'-hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl)-glycopyranoside

Biological Activity

[Description]:

Isolindleyin, a butyrophenone, is a tyrosinase inhibitor, with a Kd of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[Target]

Kd: 54.8 μM (human tyrosinase)[1]

[In Vitro]

Isolindley (1-500 μM; 7 days) suppresses melanin synthesis in human epidermal melanocytes[1].

[References]

[1]. Lee JY, et, al. Isolindleyin exerts anti-melanogenic effects in human epidermal melanocytes via direct binding to tyrosinase. Biochem Biophys Res Commun. 2021 Jan 1;534:802-807.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₆O₁₁

[ Molecular Weight ]:
478.44600

[ Exact Mass ]:
478.14800

[ PSA ]:
183.21000

[ LogP ]:
0.36840

Precursor & DownStream

Precursor

DownStream

Related Compounds

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