FINO2

Names

[ Name ]:
FINO2

[Synonym ]:
FINO2
1,2-Dioxaspiro[4.5]decane-3-ethanol, 8-(1,1-dimethylethyl)-3-methyl-
2-[(5s,8s)-3-Methyl-8-(2-methyl-2-propanyl)-1,2-dioxaspiro[4.5]dec-3-yl]ethanol

Biological Activity

[Description]:

FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> Ferroptosis

[In Vitro]

FINO2 (10 µM; 24 h) induce ferroptosis and shows iron dependence of lipid peroxidation in HT-1080 cells[1].

[References]

[1]. Gaschler MM, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
323.8±11.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₈O₃

[ Molecular Weight ]:
256.38

[ Flash Point ]:
149.6±19.3 °C

[ Exact Mass ]:
256.203857

[ LogP ]:
3.60

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.491

Related Compounds

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