Benzyl-PEG3-amine

Names

[ CAS No. ]:
86770-75-4

[ Name ]:
Benzyl-PEG3-amine

[Synonym ]:
2-(Benzyloxyethoxyethoxy)ethylamine

Biological Activity

[Description]:

Benzyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₂₁NO₃

[ Molecular Weight ]:
239.31100

[ Exact Mass ]:
239.15200

[ PSA ]:
53.71000

[ LogP ]:
2.24140

MSDS

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Safety Information

[ HS Code ]:
2922199090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%