Deleobuvir

Names

[ Name ]:
Deleobuvir

[Synonym ]:
2-Propenoic acid, 3-[2-[1-[[[2-(5-bromo-2-pyrimidinyl)-3-cyclopentyl-1-methyl-1H-indol-6-yl]carbonyl]amino]cyclobutyl]-1-methyl-1H-benzimidazol-6-yl]-, (2E)-
58BU988K90
BI 207127
(2E)-3-{2-[1-({[2-(5-Bromo-2-pyrimidinyl)-3-cyclopentyl-1-methyl-1H-indol-6-yl]carbonyl}amino)cyclobutyl]-1-methyl-1H-benzimidazol-6-yl}acrylic acid
Deleobuvir

Biological Activity

[Description]:

Deleobuvir (BI-207127, BI207127) is a potent, selective HCV NS5B polymerase inhibitor with IC50 of 50 nM against GT-1 HCV polymerase activity; demonstrates subgenomic antiviral activity against GT1b and GT1a with EC50 of 11 and 23 nM in cell-based replicon assays; shows weak or no inhibition in specificity assays that include poliovirus RdRp, mammalian DdRp II, and DNA polymerase α, β, and γ; displays good antiviral potency and tolerability in early clinical trials of short-term treatment either as a single agent or in combination with pegylated IFN-α2a/ribavirin in HCV GT1 patients. HCV Infection Phase 3 Clinical

[References]

References 1. Zeuzem S, et al. Gastroenterology. 2011 Dec;141(6):2047-55; quiz e14. 2. Zeuzem S, et al. Antivir Ther. 2013;18(8):1015-9. 3. Larrey D, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4727-35. 4. LaPlante SR, et al. J Med Chem. 2014 Mar 13;57(5):1845-54. View Related Products by Target HCV HCV Infection

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
851.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₄H₃₃BrN₆O₃

[ Molecular Weight ]:
653.568

[ Flash Point ]:
468.7±34.3 °C

[ Exact Mass ]:
652.179749

[ LogP ]:
6.15

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.736

Related Compounds

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