MKI 833

Names

[ Name ]:
MKI 833

[Synonym ]:
4-({3-chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl}amino)-6-methoxy-7-(4-pyrrolidin-1-ylpiperidin-1-yl)quinoline-3-carbonitrile
MKI-833
4-({3-chloro-4-[(1-methyl-1H-imidazole-2-yl)thio]phenyl}amino)-6-methoxy-7-(4-pyrrolidin-1-ylpiperidin-1-yl)quinoline-3-carbonitrile
UNII-7Y0IV7N95Q
Balamapimod
Balamapimod (USAN)
MKI 833

Biological Activity

[Description]:

MKI 833 (Balamapimod) is a reversible Ras/Raf/MEK inhibitor with potential anti-tumor activity.

[Related Catalog]:

Research Areas >> Cancer

[Target]

MEK

[References]

[1]. Jose R. Conejo-Garcia, et al. Methods and compositions for treatment of metastatic and refractory cancers and tumors. US20170020964A1.

[Related Small Molecules]

U0126-EtOH | PD98059 | Trametinib (GSK1120212) | PD0325901 | Selumetinib (AZD6244) | Cobimetinib | MEK162(ARRY-162,ARRY-438162) | PD184352 (CI-1040) | RO 5126766 | Isorhamnetin | AS703026 | RGB-286638 | BIX02188 | BIX02189 | SL-327

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₂ClN₇OS

[ Molecular Weight ]:
574.13900

[ Exact Mass ]:
573.20800

[ PSA ]:
110.77000

[ LogP ]:
5.88618

Synthetic Route

Click to get detail synthetic route

Related Compounds

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