Tos-PEG4-THP

Names

[ Name ]:
Tos-PEG4-THP

[Synonym ]:
Ethanol, 2-[2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]ethoxy]-, 4-methylbenzenesulfonate
MFCD28976701
2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfonate
Tos-PEG4-THP

Biological Activity

[Description]:

Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
553.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₂O₈S

[ Molecular Weight ]:
432.528

[ Flash Point ]:
288.5±30.1 °C

[ Exact Mass ]:
432.181793

[ LogP ]:
0.65

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.523

[ Storage condition ]:
2-8°C

Tos-PEG4-THP

Names

Biological Activity

Chemical & Physical Properties

Related Compounds