BM-PEG3

Names

[ CAS No. ]:
86099-06-1

[ Name ]:
BM-PEG3

[Synonym ]:
1,11-Bis-Maleimidodriethyleneglycol

Biological Activity

[Description]:

BM-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Melting Point ]:
71-72ºC

[ Molecular Formula ]:
C16H20N2O7

[ Molecular Weight ]:
352.33900

[ Exact Mass ]:
352.12700

[ PSA ]:
102.45000

[ Storage condition ]:
-20°C

Related Compounds