M617 TFA

Names

[ Name ]:
M617 TFA

[Synonym ]:
GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-GLN-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-NH2
EMDT oxalate

Biological Activity

[Description]:

M617 is a selective galanin receptor 1 (GAL1) agonist, with Kis of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Lundström, L., et al. A Galanin Receptor Subtype 1 Specific Agonist. Int J Pept Res Ther 11, 17–27 (2005).

[2]. Fang P, et al. Central injection of GalR1 agonist M617 facilitates GLUT4 expression in cardiac muscle of type 2 diabetic rats. Exp Gerontol. 2015;65:85-89.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁₂H₁₆₁N₂₉O₂₈

[ Molecular Weight ]:
2361.65000

[ Exact Mass ]:
2360.21000

[ PSA ]:
889.84000

[ LogP ]:
2.00470

Related Compounds

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