Pravastatin Lactone

Names

[ Name ]:
Pravastatin Lactone

[Synonym ]:
Butanoic acid, 2-methyl-, (1S,3S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3-hydroxy-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
[14C]-Pravastatin lactone
UNII:JBE3Z4192Q
Pravastatin lactone
Pravastatin sodium specified impurity D [EP]
pravastatin
UNII-JBE3Z4192Q
(1S,3S,7S,8S,8aR)-3-Hydroxy-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate
HMS2090H21

Biological Activity

[Description]:

Pravastatin lactone is a potent HMG-CoA inhibitor. Pravastatin Lactone is a metabolite of pravastatin. Pravastatin lactone reduces blood cholesterol levels by inhibiting cholesterol synthesis[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)

[References]

[1]. Corsini A, et, al. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res. 1995 Jan;31(1):9-27.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
590.5±50.0 °C at 760 mmHg

[ Melting Point ]:
140-143ºC

[ Molecular Formula ]:
C₂₃H₃₄O₆

[ Molecular Weight ]:
406.51

[ Flash Point ]:
199.5±23.6 °C

[ Exact Mass ]:
406.235535

[ PSA ]:
93.06000

[ LogP ]:
1.71

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.548

Pravastatin Lactone

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds