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AGN 205728

Names

[ CAS No. ]:
859498-05-8

[ Name ]:
AGN 205728

[Synonym ]:
Benzoic acid, 4-[(1E,3E)-3-[7,8-dihydro-8,8-dimethyl-5-(4-methylphenyl)-2-naphthalenyl]-3-(hydroxyimino)-1-propenyl]-
E-4-[3-(8,8-Dimethyl-5-p-tolyl-7,8-dihydronaphthalen-2-yl)-3-hydroxyiminopropenyl]benzoic acid
AGN 205728

Biological Activity

[Description]:

AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.IC50 value: 3 nM/ 0.6 nM(Ki/IC95)Target: RARγ antagonistMore information can be found in the following patent, Compound 7a.Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activityBy Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A.From PCT Int. Appl. (2005), WO 2005066115 A2 20050721.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Research Areas >> Cancer

[References]

[1]. Tsang, Kwok Yin, et al. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity. Appl. (2005), WO 2005066115 A2 20050721.


[Related Small Molecules]

Retinoic acid | AM580 | Tamibarotene | Palovarotene | Fenretinide | TTNPB | Magnolol | AGN 194310 | AGN 193109 | CD437 | Adapalene | AR-7 | Tazarotene | UVI 3003 | Tarenflurbil

Chemical & Physical Properties

[ Molecular Formula ]:
C29H27NO3

[ Molecular Weight ]:
437.53000

[ Exact Mass ]:
437.19900

[ PSA ]:
69.89000

[ LogP ]:
6.69790

[ Storage condition ]:
2-8℃

Related Compounds